Liposomal anesthetic gel for pain control during periodontal therapy in adults: A placebo-controlled randomized trial

Periodontal therapy usually requires local anesthesia. If effective, a noninvasive, liposomal anesthetic gel could increase the levels of acceptance of patients in relation to periodontal therapy.


Forty volunteers with moderate to severe chronic periodontitis were recruited, of which at least three sextants required periodontal therapy. At least one of the selected teeth had one site with a probing depth of 4 mm or greater. The volunteers received the following three gels: a placebo, lidocaine/prilocaine (Oraqix), or a liposomal lidocaine/prilocaine, which were applied to different sextants. Pain frequency was registered during treatment and the volunteers received a digital counter to register any painful or uncomfortable experiences. At the end of each session, the volunteers indicated their pain intensity using rating scales (NRS-101 and VRS-4). The volunteers had their hemodynamic parameters measured by a noninvasive digital monitor.



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