Endodontics Sponsored by GentleWave┬«

Research to explore biomarker for alternative root canal therapy

By Melissa Busch, DrBicuspid.com associate editor

February 3, 2023 -- A researcher with the University at Buffalo School of Dental Medicine in New York will explore a potential biomarker supporting the success of vital pulp therapy, an alternative, less invasive treatment than a root canal.

Dr. Hacer Aksel, clinical assistant professor of periodontics and endodontics, will study the enzyme matrix metalloproteinase (MMP)-9. Research has suggested that the enzyme is a possible biomarker for predictive factors such as the inflammatory status and healthy capacity of dental pulp. Vital pulp therapy depends on those factors, according to a press release from the university.

Aksel will further study the enzyme, because its effects on cellular functions remain unknown. Specifically, the study will investigate MMP-9's effects on pulp stem cells, inflammatory cells, and endothelial cells, which are involved in the pulpal healing process.

The results from the research will help develop new biomaterials for regenerative vital pulp therapies, Aksel said in the release.

"The long-term goal is to explore immunomodulatory hydrogel-based biomaterial to resolve pulpal inflammation while maintaining cellular functions to repair and regenerate the pulp-dentin complex during the treatment of deep caries," Aksel said. "This novel approach may open new avenues to treat other MMP-associated inflammatory diseases."

The research is funded by a grant from the American Association of Endodontists Foundation for Endodontics. The grant amount was not disclosed.

Suit dismissed against dental patient who wrote bad reviews
An appeals court in Colorado recently dismissed a defamation lawsuit filed against a dental patient who wrote negative online reviews about the root canal...
CDC probes suspected waterline-related infections
The U.S. Centers for Disease Control and Prevention (CDC) is investigating a cluster of nontuberculous mycobacteria infections in children who underwent...
AAE supports vital pulp therapy for mature teeth
The American Association of Endodontists (AAE) supports vital pulp therapy as a treatment option for patients who have adult teeth with injured pulps...
Nitrous oxide and ibuprofen may dull pulpitis pain in kids
A combination of nitrous oxide and ibuprofen may help dull the pain of children undergoing vital pulp therapy for irreversible pulpitis. A new study found...

Copyright © 2023 DrBicuspid.com

Last Updated ka 2/3/2023 9:02:10 AM