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Are pediatric sedation deaths on the rise?
By Donna Domino, Features Editor

May 18, 2010 -- In the past 15 months, four pediatric patients have died in the U.S. after undergoing sedation prior to dental treatment -- a tragic reminder of the need to ensure proper sedation training and emergency preparedness.

On May 11, a 6-year-old boy died from cardiac arrest following a dental procedure at Virginia Commonwealth University (VCU) clinic, according to a story in the Richmond Times-Dispatch.

Jacobi Hill, who had undergone sedation prior to having crowns put on several of his teeth, went into cardiac arrest shortly after the procedure was complete and the breathing tube removed, his mother, Crystal Lewis, told the Times-Dispatch. She said the boy had asthma but no other known health problems and that a pediatrician had examined him the day before and said he was fine to undergo the procedure.

According to a statement issued by VCU and obtained by Richmond, VA, television station WTVR:

Virginia Commonwealth University wants to understand what happened in connection with the tragic event involving a pediatric patient. Our internal investigation continues, and we are awaiting the results of the autopsy conducted by the Virginia Office of the Medical Examiner. We have been in contact with the patient's family, and we will continue to be available to them. VCU complies with requirements governing the administration of general anesthesia during dental procedures, and professional emergency care is immediately available in our dental clinics and facilities.

AAPD policy statement on oral sedation

Following the 2006 death of a Chicago 5-year-old, Diamond Brownridge, the American Association of Pediatric Dentistry updated its sedation guidelines to require that the person performing sedation be "qualified and appropriately trained" and have the necessary equipment and backup to use in case of an emergency.

The current AAPD policy statement reads:

"The AAPD endorses the in-office use of deep sedation or general anesthesia on select pediatric dental patients administered either by a trained, credentialed, and licensed pediatric dentist, dental or medical anesthesiologist, nurse anesthetist, or anesthesia assistant in an appropriately-equipped and staffed facility."

The boy's mother said her oldest son had had the same procedure and did not have any problems, so she thought the results would be the same with Jacobi, according to WTVR.

VCU officials did not return calls for comment.

John Rutkauskas, D.D.S., CEO of the American Academy of Pediatric Dentistry (AAPD), told DrBicuspid.com, "We will be following this case very closely."

Different sedatives

Less than three weeks before Hill's death, a 5-year-old Florida boy died while under sedation at a Gainesville dentist's office. On April 22, Dylan Shane Stewart was given chloral hydrate during an appointment with Ronnie Grundset, D.D.S., to have four fillings and eight crowns placed, according to a story in the Gainesville Sun.

The boy's siblings, a boy and a girl, had been sedated with chloral hydrate -- a commonly used sedation drug in pediatric dentistry -- during prior visits to Dr. Grundset and experienced no adverse side effects, the story said.

The Alachua County, FL, coroner is awaiting the results of toxicology tests to determine the boy's cause of death. Dr. Grundset did not return calls for comment.

In December, 22-month-old Maddoux Cordova died after his teeth were capped at the Village Specialty Surgical Center in San Antonio, according to a story in the San Antonio Express-News. His parents are suing the boy's anesthesiologist, Brian Seastrunk, M.D., and the surgical center, claiming they administered too much morphine in doses too closely together, the story said.

The boy lost oxygen to his brain shortly after the procedure and was brain-dead for two weeks before his mother decided to take him off life support, the story said.

Calls to the Bexar County medical examiner, the surgical center, and the attorney representing the boy's family were not returned.

And in February 2009, 9-year-old Cory Moore Jr. died after being sedated for a procedure by Tampa, FL, dentist R. Andrew Powless, D.M.D. Last month his parents filed a lawsuit against Dr. Powless, claiming staff should not have sedated him because he had eaten prior to the dental procedure. The Hillsborough County medical examiner said the child died of aspiration of gastric contents during administration of anesthesia for an extraction. He had been given diazepam and ketamine.

A growing trend?

Do these four cases represent a trend? To a certain extent, according to Indru Punwani, D.D.S., M.S.D., a spokesperson for the AAPD and head of the pediatric dentistry department at the University of Illinois at Chicago. Sedation is becoming more common in pediatric dental procedures because so many children are coming into dentist offices at younger ages with caries, and they sometimes need extensive work, he told DrBicuspid.com.

"The disease is appearing earlier and earlier, especially in underserved communities and immigrant populations, and sedation is often needed, particularly with very young children who need a lot of work," he said.

But pediatric sedation is safe if done correctly, he added, noting that it is routinely used without problems. "Sedation is used thousands of times every day in medical and dental procedures," he said. "It's an extremely common and safe procedure."

A child's needs and the parents' preference must be taken into consideration, Dr. Punwani noted. Nitrous oxide is one of the first tools dentists use with children who can understand instructions. But with very young children, sedation or general anesthesia is often necessary, he said.

"I've been practicing at the University of Illinois for 37 years, and we do several sedations a day without concerns," he noted. "It's a safe agent. If you follow the protocols and do things correctly, it's very rare to have problems."

Dr. Punwani cited several factors to be considered before pediatric sedation:

  • Careful case/patient selection -- only healthy children should be sedated, and dentists should check to see if the child has any pre-existing conditions, such as asthma, that could cause problems
  • Proper training, including support staff
  • Preoperative assessment
  • Good patient monitoring (blood pressure, oximetry, heart and respiratory rates)
  • Proper backup system in case of emergencies (call 911, emergency medical plans)

"Airway management for children is the primary thing, and breathing problems can lead to cardiac arrest" he said, noting that patients with large tonsils can be problematic. Sometimes the tongue can fall back, blocking a patient's airway, and the jaw needs to be moved forward.

Dr. Punwani pointed out that sedation guidelines are the same for dentists, physicians, and anesthesiologists. Training requirements for sedation vary by state, but all dental schools require one month of training for accreditation, Dr. Punwani said.

"Dentists should also carefully identify the drug protocols that they're comfortable and experienced with," he advised.

Most commonly used sedation agents in pediatric dentistry

  • Nitrous oxide
  • Chloral hydrate
  • Diazepam (Valium)
  • Midazolam (Versed)
  • Hydroxyzine (Vistaril)
  • Meperidine (Demerol)

Be prepared

The statistics support Dr. Punwani's observations. Joel Weaver, D.D.S., Ph.D., emeritus professor at Ohio State University's College of Dentistry and a consultant on anesthesia issues for the ADA, estimates the risks of an adult or child dying during anesthesia are about 1 in 350,000 to 500,000. "It happens in very rare instances," Dr. Weaver told DrBicuspid.com.

Milton Houpt, D.D.S., Ph.D., professor and chairman of pediatric dentistry at the New Jersey Dental School, noted in a 2002 survey of 1,778 pediatric dentists that most practitioners use little, if any, sedation. But there has been an overall increased use of sedation by pediatric dentists since 1985, he pointed out, primarily due to an increase in the number of practitioners who use sedation at least once a day (American Academy of Pediatric Dentistry Journal, July-Aug, 2002, Vol. 24:4, pp. 289-294). Dr. Houpt is now completing a 25-year follow up on the survey, which will be available this summer.

Even so, being prepared for office medical emergencies is critical (Journal of the American Dental Association, May 2010, Vol. 141:1, pp. 8S-13S). John Roberson, D.M.D., co-founder of the Institute of Medical Emergency Preparedness, told DrBicuspid.com there are several common issues usually involved in emergencies resulting from dental procedures:

  • Delay in calling 911
  • Delays in responding to treatment of the emergency
  • No emergency protocols in place
  • Lack of proficient staff training for emergency situations
  • Little or no documentation of event

Dr. Roberson said conducting regular mock drills and having an emergency drug kit and automated external defibrillators on hand are also important.

Most state dental boards require dentists who use sedation to have emergency procedures in place. In January, Illinois became the first state to pass a law requiring all dentists to have a medical emergency plan. "All staffers should have responsibilities and duties to deal with emergencies," Dr. Roberson said.

"Any time you put anybody to sleep, there's a theoretical risk. But if you make careful patient selection and follow guidelines and monitoring protocols, it's a very safe procedure," Dr. Punwani concluded.

Copyright © 2010 DrBicuspid.com

Ill. crafts new dental sedation rules, April 15, 2010

Woman sues sedation training firm over husband's death, March 26, 2010

Website gives overview of sedation regs by state, March 22, 2010


Last Updated 5/17/2010 5:13:20 PM

12 comments so far ...
5/19/2010 12:16:15 PM
DH
It is so sad to hear of the patient deaths that occur in dental offices.  I'm a pilot as well as a dentist...and pilot mortality during aviation accidents is usually due to ineffective use of checklists (leading to an empty fuel tank, problems with landing gear, etc...).  Like aviation, patient care in dentistry involves numerous checklists.  Among the checklists, the Safety checklist for proper administration of Sedatives in Dentistry is thorough and includes every possibly imaginable manageable error that could occur in dental procedures involving the use of sedative drugs in dentistry.    Management of the airway is paramount on this Safety checklist.   As a dentist who just learned the science of Sedation Dentistry, I plan to take every precaution treating patients with medical histories that involve a compromised airway, or any complicated medical history for that matter. 
5/19/2010 1:10:13 PM
jhirsch1971
The battle against tooth decay is a losing battle, especially when using the same ancient restorative techniques that GV Black gave us 100 years ago. What has changed since then? Yet decay rates are climbing. Children dying in dental offices is 1-500,000. If we keep believing that putting children under anesthesia is the solution that rate will increase. How many of these children who undergo GA dental treatment are back with failed restorations, extractions, abscesses within 24 months? The answer: a lot. Check the literature its documented. The problem in this approach is two fold. First dentists get paid to do something, and usually they get paid well to do all of it at once in a surgical center or hospital, greater risk greater reward. Second there are no other tools that reimburse at this level of reimbursement. Said another way there is no nonsurgical approach that can command fees with two to three zeroes involved. Industry has not given us any means of treating a microscopic bacterial infection beyond poor macroscopic surgical/excision techniques. How is it that we as dentists can still think that our handpeice can cure someone of a bacterial infection? How long can we keep this gig going?
As a pediatric dentist who understands epidemiology, I am very lucky, that our population of patients does three very remarkable things for us. One they lose their primary teeth, second they leave our care by age twenty, usually, and third, our profession does not track the efficacy of our treatments. Its carte blanche for us right now but we better beware of what is in store for us down the road. Most likely without better techniques that are measured effective we will lose our credibility as any type of healer. Thats a sad day for this profession but if we look hard in the mirror we realize that we need to do something fast. On a side note: This is no magic bullet by any stretch but why is silver diamine fluoride not allowed for sale in the US? Its fluoride..right? For heaven sake its in our drinking water without any permission, why cant a dentist try this on his patients in this country? Its alright to give them drugs to alter their mind but not to try to arrext the decay on their teeth non surgically? Can someone at the FDA explain this? Can someone at the AAPD explain this?
5/19/2010 2:35:10 PM
sampson
It is always tragic to hear of any death in a dental office, let alone a child under sedation.
 
What I found interesting about the deaths reported is that they were in multiple settings, i.e. private offices, an academic center and a surgi-center with (presumably) a licensed anesthesiologist performing the anesthetic.  Anesthesia is not without it's risks, but to imply that it is not called for in some of these situations is plain wrong.  A pediatric dentist doing full mouth restorations in one sitting is not about economics, it is about good patient care.  To be able to treat a 22 month old with stainless steel crowns under local anesthesia is not possible!  It is not the fault of the individual dentist that the child has this level of decay.  The dentist is trying to restore the problem.  The next step involves education of the parents on proper oral hygiene, nutrition and avoidance of cariogenic foods.  How about pointing the finger of blame not at dentistry but the parents, society and the food industry for promoting these products?
 
Now, back to the issue of deaths due to sedation.  Again, this is tragic.  Adequate training is of paramount importance.  We work in the airway, people.  We have to have good training.  Weekend courses are not enough.  Board of dentistry requirements are not enough.  I'm an oral and maxillofacial surgeon.  I fully support adequately trained dentists doing appropriate sedation in their offices.  What training did I have?  8 months in the operating room doing anesthesia for orthopedic, urologic, ENT, plastic, vascular and cardiac surgery.  I intubated 350 patients in that time.  I used LMA airways.  I had the distinctly unpleasurable experience of dealing with anaphylactic shock.  I completed over 500 intravenous sedations in the clinic during my residency. 
 
During my career since then, I have dealt with one episode of laryngospasm requiring succinylcholine, multiple episodes requiring positive pressure ventilation, hypotension, tachycardia, etc.  Hemodynamic changes occur with anesthetic agents.  Respiratory depression occurs.  You have to be able to manage an airway.  In my opinion, no one has any business doing any type of sedation more sophisticated that nitrous oxide without having the experience of intubating some patients.
 
I'm proud of the education and training I received.  I'm proud of my safety record in the office.  I'm proud of my specialty's safety record.   I wish every dentist that wanted to could have a similar level of training.  We need to put the politics away and look at patient safety, what kind of training works and set the minimum education standards so we do more good than harm.
 
 
5/19/2010 5:45:28 PM
Oregon EFDA gal
I'd have to agree: most of the blame lies with the parents who have allowed these ridiculous situations to befall the child in the first place.And the use of the silver diamine fluoride on baby teeth seems sound- we do amalgam restorations on them, why not a little silver to arrest the decay-so it stains a wee bit? Big deal. Its surely better than allowing rampant caries to flourish...Getting parents to maintain responsibility for their kids is hard enough when one finds that they feel if the kid can hold a toothbrush, they know how to use it. Lots of clueless parents out there...
5/20/2010 4:36:10 PM
jhirsch1971
I guess blaming the parents is our way of perpetuating what we do. Yes its their fault, but its also ours for not demanding more of our discipline. Any medical profession that is still doing the same thing as 100 years ago needs some re-examination. Especially if the procedures are not reducing disease burden. In fact disease is rising, something different needs to be done. We have to change what we do, currently Im not really sure what we do, it clearly has no therapeutic effect, decay rates in adults is climbing as a function of the failure of general dentistry and pediatric dentistry to supress disease once present. I think we just patch teeth up and pass it off as therapy. We kick the can down the road. Its not therapy, its band aids. Im practicing 9 years and I have hit a wall of frustration that for the disease population 10-20% I have little to help them defeat a microbial infection.
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